Acyclovir ointment 5%
Registration number: № LSR - 006065/08 on 31.07.2008
International nonproprietary name: Acyclovir.
The chemical name of 9- (2-hydroxy) etoksimetilguanin or 2-amino-1,9-dihydro-9- (2-hydroxy) ethoxymethyl-6H-purin-6-one.
Dosage form: ointment for external use.
Structure:
Active ingredient - 5.0 g of acyclovir
Excipients - component lipid poultry fat - Lipokomp C, macrogol 400 (polyethylene 400), emulsifier №1 (cetostearylalcohol - Lanett SX), methyl parahydroxybenzoate (nipagin), Propyl (nipazol), purified water to 100 g
Description: Homogeneous ointment from white to white with a yellowish tint.
Pharmacotherapeutic group: antiviral agent.
ATC code: D06VV03
Pharmacological properties
Acyclovir is active against Nerpes simplex types 1 and 2 virus, Varicella zoster, Epstein Barr virus and cytomegalovirus. Thymidine kinase infected cells through a series of sequential reactions actively converts acyclovir to a mono-, di-, and triphosphate of acyclovir. Last interacts with the viral DNA polymerase and incorporated into the DNA which is synthesized for new viruses. Thus, a "defective" virus DNA that results in suppression of virus replication of new generations.
Pharmacokinetics
When local use is practically not absorbed through intact skin does not fall into the systemic circulation.
Indications
Infections of the skin and mucous membranes caused by Herpes simplex virus types 1 and 2, genital herpes, herpes zoster, chickenpox.
Contraindications
Hypersensitivity to acyclovir and other ingredients.
Precautions - Pregnancy, lactation, dehydration, kidney failure.
Pregnancy and lactation
There are no adequate and well-controlled clinical studies on the safety of the drug during pregnancy has not been carried out. The application is shown only in those cases where the intended benefits to the mother outweighs the potential risk to the fetus.
The treatment period is necessary to solve the issue of termination of breastfeeding.
Dosing and Administration
Outwardly. The drug is applied 5 times per day (every 4 hours) with a thin layer to the affected and adjoining areas of the skin with them. The ointment is applied either with a cotton swab or clean hands to avoid further infection lesions. Therapy should continue until such time until the bubbles do not form a crust or until they are completely healed. The duration of therapy is an average of 5 days and must not exceed 10 days.
Side effect
Flushing, dryness, peeling skin; burning, inflammation in contact with mucous membranes. Perhaps the development of atopic dermatitis.
Interaction with other drugs
For external use have been identified interaction with other drugs.
Cautions
To achieve maximum therapeutic effect, the drug should be started as early as possible after the onset of infection (at the first sign of the disease: burning, itching, tingling sensation, a feeling of tension and redness).
Ointment should not be applied on the mucous membranes of the mouth and eyes, as may develop pronounced local inflammation. In the treatment of genital herpes should avoid sex or use condoms, because the use of acyclovir does not prevent transmission of the virus to partners.
Product form
Ointment for external use 5%. 5, 10, 15 and 30 g aluminum tubes. Each tube with instruction on use are placed in a pile of cardboard.
Storage conditions
Store in a dry, dark place at a temperature between 12 and 15 ° C.
Keep out of the reach of children.
Shelf life
2 years. Do not use beyond the expiration date printed on the package.
Conditions of supply of pharmacies:
Over the counter.
Manufacturer / organization receiving the claim:
JSC "Pharmaceutical factory of St. Petersburg."
193144, St. Petersburg, ul. Moiseenko and 24.
Tel. / Fax: (812) 271-44-34
There are contraindications to the use of read instructions or consult a specialist.