Gerviraks® cream 5%
Registration number: P number of LSR - 001797/07 on 30.07.2007
International nonproprietary name: Acyclovir
Dosage Form: Cream for external use 5%
The chemical name of 9- (2-hydroxy) etoksimetilguanin or 2-amino-1,9-dihydro-9-
(2-hydroxy) ethoxymethyl-6H-purin-6-one.
Structure:
Active ingredient - acyclovir 5 g
Excipients - nipazol, nipagin, Cremophor A6, A25 Cremophor, cetyl alcohol, propylene glycol, liquid paraffin oil, purified water.
Description:
A homogeneous cream white.
Pharmacotherapeutic group: antiviral agent.
ATC code: D06BB03
Pharmacological properties:
Acyclovir is active against Herpes simplex type 1 and 2 virus, Varicella zoster, Epstein Barr virus and cytomegalovirus. Thymidine kinase infected cells through a series of sequential reactions actively converts acyclovir to a mono-, di-, and triphosphate of acyclovir. Last interacts with the viral DNA polymerase and incorporated into the DNA which is synthesized for new viruses. Thus, a "defective" virus DNA that results in suppression of virus replication of new generations.
Pharmacokinetics:
When local use is practically not absorbed through intact skin does not fall into the systemic circulation.
Indications:
Infections of the skin and mucous membranes caused by Herpes simplex virus types 1 and 2, genital herpes, herpes zoster, chickenpox.
Contraindications:
Hypersensitivity to acyclovir and other ingredients.
Precautions - Pregnancy, lactation, dehydration, kidney failure.
Pregnancy and lactation:
There are no adequate and well-controlled clinical studies on the safety of the drug during pregnancy has not been carried out. The application is shown only in those cases where the intended benefits to the mother outweighs the potential risk to the fetus.
The treatment period is necessary to solve the issue of termination grudnogovskarmlivaniya.
Dosage and administration:
Outwardly. The drug is applied 5 times per day (every 4 hours) with a thin layer to the affected and adjoining areas of the skin with them. The cream is applied either with a cotton swab or clean hands to avoid further infection lesions. Therapy should continue until such time until the bubbles do not form a crust or until they are completely healed. The duration of therapy is an average of 5 days and must not exceed 10 days.
Side effect:
Flushing, dryness, peeling skin; burning, inflammation in contact with mucous membranes. Perhaps the development of atopic dermatitis.
Interaction with other drugs:
For external use have been identified interaction with other drugs.
Special instructions:
To achieve maximum therapeutic effect of the drug is necessary to adopt as soon as possible after the onset of infection (at the first sign of the disease: burning, itching, tingling sensation, a feeling of tension and redness).
Cream should not be applied on the mucous membranes of the mouth and eyes, as may develop pronounced local inflammation. In the treatment of genital herpes should avoid sex or use condoms, because the use of acyclovir does not prevent transmission of the virus to partners.
Product:
5% cream for topical application in aluminum tubes 3, 5, 10, together with instructions for use placed in a pile of cardboard.
Storage conditions:
List B. The temperature is from 12 to 15 °C. Keep out of the reach of children.
Shelf life:
2 years. Do not use after the expiration date printed on the package.
Conditions of supply:
Over the counter.
The enterprise-manufacturer / organization receiving the claim:
JSC "Pharmaceutical factory of St. Petersburg," Russia,
193144, St. Petersburg, ul. Moiseenko and 24. tel / fax: (812) 271 4434
There are contraindications to the use of read instructions or consult a specialist.